Selective serotonin reuptake inhibitors (SSRIs) learning module - main section

6 Self-assessment

This self-assessment exercise comprises six questions. Please think about the single best answer for each question and then check the feedback to see if you are correct. (click on the answer to see the feedback)

Question 1

Which of the following statements is correct?

Question 2

Which of the following is NOT a characteristic adverse effect of SSRIs?

  • Venous thromboembolism


    Correct

    SSRIs do not generally increase the risk of venous thromboembolism. Drugs that increase platelet aggregation are more likely to cause thromboembolic effects; SSRIs in fact reduce the ability of platelets to aggregate.

    Close

  • Rare risk of serotonin syndrome


    Review the module notes and select another response

    Though very rare, serotonin syndrome typically occurs when an SSRI is taken with another drug that enhances its serotonergic effect or in overdose.

    Close

  • Erectile dysfunction


    Review the module notes and select another response

    Sexual dysfunction, including erectile disorders do occur with SSRIs. But it is important to remember that depression is also associated with changes in sexual function.

    Close

  • Increased gastric motility


    Review the module notes and select another response

    Nausea occurs frequently, especially when SSRI treatment is initiated; other gastrointestinal effects associated with SSRIs include vomiting, dyspepsia, and diarrhoea.

    Close

  • Increased sweating


    Review the module notes and select another response

    Excessive sweating can occur as a result of SSRI treatment; it can also occur when SSRI treatment is being withdrawn.

    Close

Question 3

The following is a selection of adverse effects of various antidepressants. Which one of these effects is specific to antidepressants that inhibit serotonin reuptake?

  • Dry mouth


    Review the module notes and select another response

    Dry mouth can result from treatment with a variety of antidepressants; for example, the antimuscarinic effects of tricyclic antidepressants include dry mouth.

    Close

  • Withdrawal (discontinuation) reactions


    Review the module notes and select another response

    Although some features of withdrawal reactions might be different, withdrawal effects can occur with tricyclic antidepressants, serotonin–noradrenaline reuptake inhibitors, as well as SSRIs.

    Close

  • Inappropriate secretion of antidiuretic hormone and risk of hyponatraemia


    Review the module notes and select another response

    Though probably more frequent with SSRIs, hyponatraemia (often as a result of syndrome of inappropriate secretion of antidiuretic hormone [SIADH]), can occur with diverse antidepressants.

    Close

  • Anti-aggregatory effect on platelets with increased risk of bleeding


    Correct

    Serotonergic mechanism is involved in platelet aggregation and this effect is therefore associated with antidepressants which inhibit serotonin reuptake.

    Close

  • Sleep disturbances


    Review the module notes and select another response

    Insomnia or drowsiness are associated with most antidepressant drugs. Moreover, changes in mood can also affect sleep patterns.

    Close

Question 4

Which of the following statements is NOT correct?

Question 5

Which of the following statements about SSRI withdrawal effects is true?

Question 6

Which of these statements is NOT correct?

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Page last modified: 17 February 2015