Selective serotonin reuptake inhibitors (SSRIs) learning module - main section

4.14 Antimuscarinic (anticholinergic) effects

Man rubbing his eyes

Rare and very rare, but potentially serious adverse effects.

Antimuscarinic effects, such as visual disturbance, tachycardia and urinary retention, can occur with SSRIs but they are generally less marked than with tricyclic antidepressants (and in some cases are negligible).

Risk-reduction measures

In patients with prostatic enlargement or angle-closure glaucoma an antidepressant with negligible antimuscarinic effects should ideally be selected.

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Page last modified: 17 February 2015