This report was published in 2010. For more recent information, please see the European public assessment report for NSAIDs and cardiovascular risk and the Drug Safety Update articles on diclofenac, aceclofenac, and high-dose ibuprofen
01 January 2010
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat pain and swelling in diseases such as arthritis.
The following report summarises two studies which looked at the risk of cardiovascular events (such as heart attacks) with NSAID use in the general population. The results from the studies suggest that all users of NSAIDs may be at an increased risk of cardiovascular events, and that the lowest effective dose and shortest duration of treatment should be used.
This information has also been highlighted in Drug Safety Update (February 2009)
This report presents the evidence that was available when the regulatory decision was made, showing a ‘snapshot’ of the clinical landscape at the time. However, any advice in this report remains current unless it is superseded by a more recent report (where relevant, this is indicated).