Risk of venous thromboembolism associated with antipsychotics


01 June 2009

Antipsychotic drugs are mainly used to treat mental health conditions such as schizophrenia, agitation, severe anxiety, mania and violent or dangerously compulsive behaviour.

A review of UK Yellow Card data and published studies on antipsychotics and the risk of venous thromboembolism (VTE; dangerous blood clots in the circulatory system) has concluded that an increase in risk of VTE cannot be excluded.

This safety concern has also been highlighted in the June 2009 issue of Drug Safety Update (page 2)PDF file (opens in new window) (282Kb).

More information on antipsychotic medication can be found in the product-specific information and advice section of our website.

This report presents the evidence that was available when the regulatory decision was made, showing a ‘snapshot’ of the clinical landscape at the time. However, any advice in this report remains current unless it is superseded by a more recent report (where relevant, this is indicated).

Page last modified: 11 February 2016