Benzodiazepines learning module

1.1 Class members

Benzodiazepine

Licensed indications*

Formulations

Strengths

alprazolam

Moderate to severe anxiety states; anxiety associated with depression

Tablets

250 micrograms, 500 micrograms

chlordiazepoxide

Disabling or unacceptably distressing anxiety; muscle spasm; alcohol withdrawal

Tablets

5 mg, 10 mg

clobazam

Disabling or unacceptably distressing anxiety; anxiety associated with depression (in conjunction with other treatment); adjunctive therapy of epilepsy

Tablets

10 mg

clonazepam

Epileptic disease

Tablets

500 micrograms, 2 mg

Status epilepticus

Injection

1 mg/ml: 1 ml

diazepam

Disabling or unacceptably distressing anxiety; cerebral palsy; muscle spasm; adjunctive treat­ment of epilepsy; alcohol withdrawal; premedi­cation before dental procedures or before surgery

Tablets

2 mg, 5 mg, 10 mg

Oral solution

2 mg/5 ml, 5 mg/5 ml

Sedation before medical procedures; premedication before surgery; muscle spasm (eg in tetanus or poisoning); status epilepticus; severe acute anxiety or agitation (eg delirium tremens)

Injection solution

5 mg/ml: 2 ml

Injection emulsion

5 mg/ml: 2 ml

Severe acute anxiety or agitation; convulsions; muscle spasm (eg in tetanus or poisoning); sedation before medical procedures

Rectal solution

2 mg/ml: 1.25 ml, 2.5 ml
4 mg/ml:
2.5 ml

flurazepam

Disabling or unacceptably distressing insomnia

Capsules

15 mg, 30 mg

loprazolam

Disabling or unacceptably distressing insomnia

Tablets

1 mg

lorazepam

Disabling or unacceptably distressing anxiety; premedication before dental procedures or before surgery

Tablets

1 mg, 2.5 mg

Premedication before medical procedures; acute anxiety, excitement or mania; status epilepticus

Injection

4 mg/ml: 1 ml

lormetazepam

Disabling or unacceptably distressing insomnia

Tablets

500 micrograms, 1 mg

midazolam

Acute prolonged convulsive seizures

Oromucosal solution

5 mg/ml: 0.5 ml, 1 ml, 1.5 ml, 2 ml

Sedation before medical procedures; premedication before surgery; induction of anaesthesia; sedative in combined anaesthesia; sedation for patients in intensive care

Injection

1 mg/ml: 2 ml, 5 ml, 10 ml
2 mg/ml:
5 ml, 25 ml, 50 ml
5 mg/ml:
1 ml, 2 ml, 3 ml, 5 ml, 10 ml

nitrazepam

Disabling or unacceptably distressing insomnia

Tablets

5 mg

Oral suspension

2.5 mg/5 ml

oxazepam

Disabling or unacceptably distressing anxiety

Tablets

10 mg, 15 mg

temazepam

Disabling or unacceptably distressing insomnia; premedication before medical procedures

Tablets

10 mg, 20 mg

Oral solution

10 mg/5 ml

*Consult summaries of product characteristics for up to date statements on authorised indications


Did you know...

Diazepam is absorbed more rapidly and less erratically from oral tablets than from intramuscular injection. If rapid effect is needed, it is best to give diazepam either intravenously or as a rectal solution. Alternatives to diazepam include lorazepam by intravenous injection and oromucosal (‘buccal’) tablets of midazolam.

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Page last modified: 17 February 2015