3.3 Cardiovascular adverse effects
Cardiovascular effects of antipsychotics include:
- Blood pressure changes
- Cerebrovascular events such as stroke
- Cardiac rhythm disorders, particularly prolongation of the QT interval
- Venous thromboembolism
Disease of the cardiovascular system may be more prevalent in patients with schizophrenia than in the general population; the risk might be further increased by the use of several medicines (polypharmacy), especially in the elderly. Vigilance is needed to detect cardiovascular disorders.
Sudden transient loss of consciousness (syncope) associated with antipsychotic use may result from blood pressure change (especially postural hypotension) or, less commonly, from cardiac rhythm disturbance.
The use of clozapine has been associated with myocarditis and cardiomyopathy—see under Clozapine.
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