9 March 2004
New expert advice issued today recommends that two atypical antipsychotic drugs, risperidone and olanzapine, should not be used to treat behavioural problems in older patients with dementia.The Committee on Safety of Medicines (CSM) has reviewed the data for risperidone and olanzapine. The evidence showed that there is a three-fold increase in the risk of stroke for risperidone when used in older patients with dementia. It showed there was a similar risk with olanzapine.The following documents are available:
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› A question and answer document.
› Summary of clinical trial data on cerebrovascular adverse events (CVAEs) in randomised clinical trials of risperidone conducted in patients with dementia.
› Press statement.