Yellow Card Scheme

The MHRA and the Commission on Human Medicines (CHM) run the UK's spontaneous adverse drug reaction reporting scheme - called the Yellow Card Scheme. This receives reports of suspected adverse drug reactions (ADRs) from healthcare professionals. More recently the scheme was extended to included direct reporting by patients.

The MHRA and its predecessor organisations have collected reports of suspected adverse drug reactions through the Yellow Card Scheme for over 40 years. Since the establishment of the Yellow Card Scheme over 500,000 UK reports have been collected.

We collect Yellow Card reports from both health professionals and members of the public on:

  • prescription medicines;
  • herbal remedies; and 
  • over-the-counter (OTC) medicines.

The MHRA and CHM also have five Yellow Card Centres whose role focuses on follow-up of reports in their areas as this has been shown to improve follow-up rates.  (Reporters may request follow-up by MHRA if they would prefer this.):

  • Yellow Card Centre Mersey, Freepost, Liverpool. L3 3AB.
  • Yellow Card Centre Wales, Freepost, Cardiff, CF4 1ZZ.
  • Yellow Card Centre Scotland, 51 Little France Crescent, Old Dalkeith Road, Edinburgh. EH16 4SA.
  • Yellow Card Centre Northern and Yorkshire, Freepost ,Newcastle-upon-Tyne. NE1 1BR.
  • Yellow Card Centre West Midlands, Freepost, Birmingham. B18 7BR.

Patient reporting
Patients are now welcome to directly report suspected adverse drug reactions to the MHRA through the Yellow Card Scheme. Until recently, only health professionals were able to make Yellow Card reports.

Healthcare professional reporting of suspected adverse drug reactions
Patient reporting of suspected adverse drug reactions


Page last modified: 04 March 2008