In April 2005, patients given tamsulosin for treatment of benign prostatic hyperplasia were identified as having an increased risk of Intraoperative Floppy Iris Syndrome (IFIS)—a newly diagnosed syndrome that can lead to surgical complications during cataract surgery. Tamsulosin belongs to a class of drugs called α-1 adrenoceptor antagonists.
The following report discusses the data used in the regulatory assessment of a potential class effect of α-1 adrenoceptor antagonists and development of IFIS. These data suggest that IFIS can develop in a few patients given this class of drug. Patients should tell their cataract surgeon about past and current use of α-1 adrenoceptor antagonists before surgery to ensure appropriate measures are in place should IFIS occur.
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Public Assessment Report - Intraoperative floppy iris syndrome (IFIS) and α-1 adrenoceptor antagonists- a class effect?
(153Kb)
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Current Problems in Pharmacovigilance: Volume 31 (pages 1-12) May 2006
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Dear Healthcare Professional letter to ophthalmologists, urologists, and general practitioners, July 2006 (23Kb)
