Drug Safety Update

Volume 4, Issue 3 October 2010

Latest advice for medicines users

Implanon contraceptive implant: changing to Nexplanon

Article date: October 2010
In October 2010, Nexplanon replaces the Implanon contraceptive implant. Nexplanon is a radio-opaque version with a new insertion mechanism. All healthcare professionals who are trained in inserting Implanon will need to make sure they are trained in using Nexplanon before the changeover. This should include model-arm training with a placebo implant

Subdermal contraceptive implants containing etonogestrel

To date, the only available subdermal implant used for contraception in the UK has been Implanon, which contains 68 mg etonogestrel. In October this year, a new product—called Nexplanon—replaces Implanon. Nexplanon also contains 68 mg etonogestrel and is bioequivalent to Implanon. Similar to Implanon, Nexplanon can be used for up to 3 years, and is removed in the same way as Implanon.

What is changing?

Nexplanon differs from Implanon in two ways:

  • it has a new preloaded applicator, designed to reduce the risk of insertion errors
  • it is radio-opaque (it contains barium) and can therefore be located on an X-ray or CT scan, if necessary

Actions required: currently trained Implanon inserters

Practitioners who currently insert Implanon should become familiar with the new Nexplanon, and should complete both theoretical and practical training before attempting to use it. An online visual training programme includes animation of the insertion technique. Once completed, model-arm training with a placebo implant is strongly recommended. Further details about the training programme and how to obtain placebo devices can be found on the manufacturer’s website: www.nexplanon.co.uk/training, or by contacting 0844 556 1444. Further details about training can also be found at the Faculty of Sexual and Reproductive Healthcare website www.ffprhc.org.uk/

What will happen to current stock of Implanon?

Implanon will now be discontinued. However, you can continue to prescribe, dispense, or fit any remaining Implanon stock you may have.

Advice for healthcare professionals:

  • It is essential that trained inserters of Implanon obtain practical and theoretical experience before changing to Nexplanon. This should include model-arm training with a placebo implant

See also letter for healthcare professionals sent September 2010.

Nexplanon is also our highlighted Patient Information Leaflet of the month (see article O1).


Article citation: Drug Safety Update Oct 2010, vol 4 issue 3: A1.


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Page last modified: 14 January 2011