Further information on SSRIs
British National Formulary (external link)
Martindale: the complete drug reference (external link)
Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association of Psychopharmacology guidelines (external link)
NICE. Depression: the treatment and management of depression in adults - clinical guideline 90, issued October 2009 (external link)
NICE. Depression in adults with a chronic physical health problem - clinical guideline 91, issued October 2009 (external link)
| Source (MHRA website) | Article title | Comment |
| Current Problems in Pharmacovigilance: Volume 26 | Selective serotonin reuptake inhibitors (SSRIs) | A review of the Yellow Card reports, published literature and current product information has identified adverse reactions which can be considered common to all SSRIs and these are listed. |
| Committee on Safety of Medicines (CSM) | Report of the CSM Expert Working Group on the safety of selective serotonin reuptake inhibitor antidepressants (2004) | A review of the evidence on aspects such as use in children, adolescents and young people, suicidal behaviour; withdrawal reactions and dosing. |
| Drug Safety Update Aug 2007 | Antidepressants: suicidal behaviour | Young adults on antidepressant treatment should be monitored closely. |
| Drug Safety Update Apr 2008 | Antidepressants: suicidal thoughts and behaviour - summary report | Summary of European and US Food and Drug Administration assessment of suicide risk. |
| Drug Safety Update Aug 2009 | Monitoring the impact of regulatory action taken by the MHRA |
Commissioned research programme: The impact of regulatory action taken by the MHRA on SSRIs. |
| Drug Safety Update Mar 2010 | Fluoxetine: possible small risk of congenital cardiac defects | Possible small increased risk of congenital cardiac defects in association with fluoxetine in early pregnancy, similar to that with paroxetine. There are insufficient data to draw conclusions on whether there is a similar risk for other SSRIs. |
| Drug Safety Update May 2010 | SSRIs and SNRIs: risk of persistent pulmonary hypertension in the newborn | SSRIs in pregnancy, particularly in the later stages, may increase the risk of persistent pulmonary hypertension in the newborn. |
| Drug Safety Update May 2010 | Antidepressants: risk of fractures | Small increased risk of fractures associated with TCAs and SSRIs |
| Drug Safety Update Nov 2010 | Tamoxifen for breast cancer: drug interactions involving CYP2D6, genetic variants, and variability in clinical response | Concomitant use of medicines known to be potent CYP2D6 inhibitors should be avoided whenever possible in patients treated with tamoxifen. Such drugs include paroxetine, fluoxetine, bupropion, quinidine and cinacalcet. |
| Product-specific information and advice from the MHRA | Selective serotonin reuptake inhibitors and serotonin and noradrenaline reuptake inhibitors | Key areas of safety concerns with SSRI and SNRIs. |
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